Michaelis Menten equation (bi bi reaction ping pong with products 1 and 2 - Michaelis Menten model - steady state assumption)

Community: MathModDB

mathematical expression

Available identifiers

MaRDI QIDQ6674201

equation for bi bi reaction with ping pong mechanism with products 1 and 2 following steady state assumption, named after Leonor Michaelis, Maud Menten

Defining Formula: $v_{0} = \frac{V_{1} V_{2} (c_{S_{1}} c_{S_{2}} - \frac{c_{P_{1}} c_{P_{2}}}{K_{e q}})}{V_{2} K_{S_{2}} c_{S_{1}} + V_{2} K_{S_{1}} c_{S_{2}} + \frac{V_{1} K_{P_{2}}}{K_{e q}} c_{P_{2}} + \frac{V_{1} K_{P_{1}}}{K_{e q}} c_{P_{2}} + V_{2} c_{S_{1}} c_{S_{2}} + \frac{V_{1} K_{P_{2}}}{K_{i S_{1}} K_{e q}} c_{S_{1}} c_{P_{1}} + \frac{V_{1}}{K_{e q}} c_{P_{1}} c_{P_{2}} + \frac{V_{2} K_{S_{1}}}{K_{i P_{2}}} c_{S_{2}} c_{P_{2}}}$
$K_{P_{1}}$ represents Michaelis constant
$K_{P_{2}}$ represents Michaelis constant
$K_{S_{1}}$ represents Michaelis constant
$K_{S_{2}}$ represents Michaelis constant
$K_{e q}$ represents equilibrium constant
$K_{i P_{1}}$ represents inhibition constant
$K_{i P_{2}}$ represents inhibition constant
$K_{i S_{1}}$ represents inhibition constant
$K_{i S_{2}}$ represents inhibition constant
$V_{1}$ represents reaction rate
$V_{2}$ represents reaction rate
$c_{P_{1}}$ represents concentration
$c_{P_{2}}$ represents concentration
$c_{S_{1}}$ represents concentration
$c_{S_{2}}$ represents concentration
$v_{0}$ represents reaction rate

List of contained entities

Michaelis constant product 1 (bi bi reaction ping pong - Michaelis Menten model - steady state assumption)	$K_{P_{1}} = \frac{k_{- 3} (k_{- 1} + k_{2})}{k_{- 2} (k_{- 1} + k_{- 3})}$
	$K_{P_{1}}$ represents Michaelis constant
	$k_{- 1}$ represents reaction rate constant
	$k_{- 2}$ represents reaction rate constant
	$k_{- 3}$ represents reaction rate constant
	$k_{2}$ represents reaction rate constant

Michaelis constant product 2 (bi bi reaction ping pong - Michaelis Menten model - steady state assumption)	$K_{P_{2}} = \frac{k_{- 1} (k_{- 3} + k_{4})}{k_{- 4} (k_{- 1} + k_{- 3})}$
	$K_{P_{2}}$ represents Michaelis constant
	$k_{- 1}$ represents reaction rate constant
	$k_{- 3}$ represents reaction rate constant
	$k_{- 4}$ represents reaction rate constant
	$k_{4}$ represents reaction rate constant

Michaelis constant substrate 1 (bi bi reaction ping pong - Michaelis Menten model - steady state assumption)	$K_{S_{1}} = \frac{k_{4} (k_{- 1} + k_{2})}{k_{1} (k_{2} + k_{4})}$
	$K_{S_{1}}$ represents Michaelis constant
	$k_{- 1}$ represents reaction rate constant
	$k_{1}$ represents reaction rate constant
	$k_{2}$ represents reaction rate constant
	$k_{4}$ represents reaction rate constant

Michaelis constant substrate 2 (bi bi reaction ping pong - Michaelis Menten model - steady state assumption)	$K_{S_{2}} = \frac{k_{2} (k_{- 3} + k_{4})}{k_{3} (k_{2} + k_{4})}$
	$K_{S_{2}}$ represents Michaelis constant
	$k_{- 3}$ represents reaction rate constant
	$k_{2}$ represents reaction rate constant
	$k_{3}$ represents reaction rate constant
	$k_{4}$ represents reaction rate constant

equilibrium constant (bi bi reaction ping pong - Michaelis Menten model - steady state assumption)	$K_{e q} = \frac{k_{1} k_{2} k_{3} k_{4}}{k_{- 1} k_{- 2} k_{- 3} k_{- 4}}$
	$K_{e q}$ represents equilibrium constant
	$k_{- 1}$ represents reaction rate constant
	$k_{- 2}$ represents reaction rate constant
	$k_{- 3}$ represents reaction rate constant
	$k_{- 4}$ represents reaction rate constant
	$k_{1}$ represents reaction rate constant
	$k_{2}$ represents reaction rate constant
	$k_{3}$ represents reaction rate constant
	$k_{4}$ represents reaction rate constant

inhibition constant product 1 (bi bi reaction ping pong - Michaelis Menten model - steady state assumption)	$K_{i P_{1}} = \frac{k_{2}}{k_{- 2}}$
	$K_{i P_{1}}$ represents inhibition constant
	$k_{- 2}$ represents reaction rate constant
	$k_{2}$ represents reaction rate constant

inhibition constant product 2 (bi bi reaction ping pong - Michaelis Menten model - steady state assumption)	$K_{i P_{2}} = \frac{k_{4}}{k_{- 4}}$
	$K_{i P_{2}}$ represents inhibition constant
	$k_{- 4}$ represents reaction rate constant
	$k_{4}$ represents reaction rate constant

inhibition constant substrate 1 (bi bi reaction ping pong - Michaelis Menten model - steady state assumption)	$K_{i S_{1}} = \frac{k_{- 1}}{k_{1}}$
	$K_{i S_{1}}$ represents inhibition constant
	$k_{- 1}$ represents reaction rate constant
	$k_{1}$ represents reaction rate constant

inhibition constant substrate 2 (bi bi reaction ping pong - Michaelis Menten model - steady state assumption)	$K_{i S_{2}} = \frac{k_{- 3}}{k_{3}}$
	$K_{i S_{2}}$ represents inhibition constant
	$k_{- 3}$ represents reaction rate constant
	$k_{3}$ represents reaction rate constant

limiting reaction rate backward (bi bi reaction ping pong)	$V_{2} = \frac{k_{- 1} k_{- 3}}{k_{- 1} + k_{- 3}} c_{E_{0}}$
	$V_{2}$ represents reaction rate
	$c_{E_{0}}$ represents concentration
	$k_{- 1}$ represents reaction rate constant
	$k_{- 3}$ represents reaction rate constant

limiting reaction rate forward (bi bi reaction ping pong)	$V_{1} = \frac{k_{2} k_{4}}{k_{2} + k_{4}} c_{E_{0}}$
	$V_{1}$ represents reaction rate
	$c_{E_{0}}$ represents concentration
	$k_{2}$ represents reaction rate constant
	$k_{4}$ represents reaction rate constant

Mathematical expressions specializing Michaelis Menten equation (bi bi reaction ping pong with products 1 and 2 - Michaelis Menten model - steady state assumption)

Michaelis Menten equation (bi bi reaction ping pong with product 1 - Michaelis Menten model - steady state assumption)
Michaelis Menten equation (bi bi reaction ping pong with product 2 - Michaelis Menten model - steady state assumption)
Michaelis Menten equation (bi bi reaction ping pong without products - Michaelis Menten model - steady state assumption)

Further items linking to Michaelis Menten equation (bi bi reaction ping pong with products 1 and 2 - Michaelis Menten model - steady state assumption)

Item	Property
bi bi reaction Ping Pong mechanism Michaelis Menten model with products 1 and 2 (steady state assumption)	contains

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