Hill model (enzyme kinetics) (Q6775834)

The Hill model in enzyme kinetics is an empirical rate law used to describe cooperative substrate binding and the resulting sigmoidal dependence of initial reaction velocity on substrate concentration. It generalizes the Michaelis–Menten equation by introducing a Hill coefficient that quantifies positive or negative cooperativity among substrate-binding events. The model captures catalytic saturation behavior and provides parameters describing maximal velocity and substrate sensitivity. When the Hill coefficient equals one, the model reduces to the classical non-cooperative Michaelis–Menten form. The Hill enzyme-kinetics model is applied to cooperative or allosteric enzymes in biochemistry and systems biology.