A modeling framework for electro-mechanical interaction between excitable deformable cells
From MaRDI portal
Abstract: Cardiac myocytes are the fundamental cells composing the heart muscle. The propagation of electric signals and chemical quantities through them is responsible for their nonlinear contraction and dilatation. In this study, a theoretical model and a finite element formulation are proposed for the simulation of adhesive contact interactions between myocytes across the so-called gap junctions. A multi-field interface constitutive law is proposed for their description, integrating the adhesive and contact mechanical response with their electrophysiological behavior. From the computational point of view, the initial and boundary value problem is formulated as a structure-structure interaction problem, which leads to a straightforward implementation amenable for parallel computations. Numerical tests are conducted on different couples of myocytes, characterized by different shapes related to their stages of growth, capturing the experimental response. The proposed framework is expected to have impact on the understanding how imperfect mechano-transduction could lead to emergent pathological responses.
Recommendations
- Excitation-contraction coupling between human atrial myocytes with fibroblasts and stretch activated channel current: a simulation study
- Electro-mechanical coupling in a one-dimensional model of heart muscle fiber
- Mathematical modelling of active contraction in isolated cardiomyocytes
- Modeling cardiac mechanics on a sub-cellular scale
- Thermodynamically consistent orthotropic activation model capturing ventricular systolic wall thickening in cardiac electromechanics
Cites work
- scientific article; zbMATH DE number 2233866 (Why is no real title available?)
- A bio-mechanical model for coupling cell contractility with focal adhesion formation
- A consistent interface element formulation for geometrical and material nonlinearities
- A coupled cohesive zone model for transient analysis of thermoelastic interface debonding
- A unified interface constitutive law for the study of fracture and contact problems in heterogeneous materials
- An active strain electromechanical model for cardiac tissue
- An integrated formulation of anisotropic force-calcium relations driving spatio-temporal contractions of cardiac myocytes
- Biomechanics: trends in modeling and simulation
- Computational Contact Mechanics
- Computational modeling of non-linear diffusion in cardiac electrophysiology: a novel porous-medium approach
- Computational vascular fluid dynamics: problems, models and methods
- Electromechanical coupling in cardiac dynamics: the active strain approach
- Inexact accurate partitioned algorithms for fluid-structure interaction problems with finite elasticity in haemodynamics
- Integrated heart -- coupling multiscale and multiphysics models for the simulation of the cardiac function
- Mathematical modelling of active contraction in isolated cardiomyocytes
- Mathematical physiology. I: Cellular physiology
- Micro-slip of rough surfaces under cyclic tangential loading
- New development in freefem++
- Node-to-segment and node-to-surface interface finite elements for fracture mechanics
- Review Paper: Continuum biomechanics of soft biological tissues
- Visco-electro-elastic models of fiber-distributed active tissues
Cited in
(12)- Efficient estimation of cardiac conductivities: a proper generalized decomposition approach
- Modeling cardiac mechanics on a sub-cellular scale
- A multi-scale FEM-BEM formulation for contact mechanics between rough surfaces
- Modeling Excitable Tissue
- An agent-based model for elasto-plastic mechanical interactions between cells, basement membrane and extracellular matrix
- Numerical approximation of a 3D mechanochemical interface model for skin patterning
- scientific article; zbMATH DE number 2106784 (Why is no real title available?)
- A combined phase-field and cohesive zone model approach for crack propagation in layered structures made of nonlinear rubber-like materials
- The dynamics of electrically interacting cells
- Qualitative modeling of mechanoelectrical feedback in a ventricular cell
- Key aspects for effective mathematical modelling of fractional-diffusion in cardiac electrophysiology: a quantitative study
- A note on stress-driven anisotropic diffusion and its role in active deformable media
This page was built for publication: A modeling framework for electro-mechanical interaction between excitable deformable cells
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1797667)
