A non-parametric optimal design algorithm for population pharmacokinetics

DOI10.1007/978-3-031-87804-6_12MaRDI QIDQ7238107zbMATH OpenFDO

Authors Markus Hovd, Alona Kryshchenko, Michael N. Neely, Julian Otalvaro, Alan Schumitzky, Walter M. Yamada

Publication date 5 May 2026

Full work available at URL https://doi.org/10.1007/978-3-031-87804-6_12

zbMATH Keywords

high-dimensional statisticsmixture distributionmixture modelnonparametric maximum likelihoodoptimal designpopulation modelprimal-dual interior-point method

Mathematics Subject Classification ID

Classification and discrimination; cluster analysis (statistical aspects) (62H30) Statistical aspects of big data and data science (62R07) Artificial intelligence (68Txx)

Cites work

• A maximum likelihood estimation method for random coefficient regression models
• An Algorithm for Computing the Nonparametric MLE of a Mixing Distribution
• Constructing Sobol Sequences with Better Two-Dimensional Projections
• scientific article; zbMATH DE number 2002582 (Why is no real title available?)
• Nonparametric EM algorithms for estimating prior distributions
• Population pharmacokinetic/pharmacodynamic mixture models via maximum a posteriori estimation
• Remark on algorithm 659
• The geometry of mixture likelihoods: A general theory

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