A spatial filtering approach to biological patterning

DOI10.1137/18M1216092MaRDI QIDQ5206965zbMATH OpenFDO

Authors Melinda Liu Perkins, Murat Arcak

Publication date 19 December 2019

Published in SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1902.04614, https://epubs.siam.org/doi/pdf/10.1137/18M1216092

zbMATH Keywords

developmental biologypattern formationperturbation analysisprepattern processing

Mathematics Subject Classification ID

Developmental biology, pattern formation (92C15)

Abstract: Interactions between neighboring cells are essential for generating or refining patterns in a number of biological systems. We propose a discrete filtering approach to predict how networks of cells modulate spatially varying input signals to produce more complicated or precise output signals. The interconnections between cells determine the set of spatial modes that are amplified or suppressed based on the coupling and internal dynamics of each cell, analogously to the way a traditional digital filter modifies the frequency components of a discrete signal. We apply the framework to two systems in developmental biology: the Notch-Delta interaction that shapes extit{Drosophila} wing veins and the Sox9/Bmp/Wnt network responsible for digit formation in vertebrate limbs. The latter case study demonstrates that Turing-like patterns may occur even in the absence of instabilities. Results also indicate that developmental biological systems may be inherently robust to both correlated and uncorrelated noise sources. Our work shows that a spatial frequency-based interpretation simplifies the process of predicting patterning in living organisms when both environmental influences and intercellular interactions are present.

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Cites work

• A graph partitioning approach to predicting patterns in lateral inhibition systems
• A theory of biological pattern formation
• Componentwise energy amplification in channel flows
• Distributed control of spatially invariant systems
• Pattern Formation and Dynamics in Nonequilibrium Systems
• Pattern Formation by Lateral Inhibition in Large-Scale Networks of Cells
• The chemical basis of morphogenesis
• The Discrete Cosine Transform
• The Intersection of Theory and Application in Elucidating Pattern Formation in Developmental Biology

Cited in

(6)

• Resonant filtering of compositional waves in multicellular networks
• Spatial pattern formation in biology: I. Dermal wound healing. II. Bacterial patterns
• A graph partitioning approach to predicting patterns in lateral inhibition systems
• Boundary formation by notch signaling in drosophila multicellular systems: eperimental observations and gene network modeling by genomic object net
• Morphometry of spatial patterns
• Dynamics of Notch activity in a model of interacting signaling pathways

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