A unified framework for weighted parametric multiple test procedures

DOI10.1002/BIMJ.201600233MaRDI QIDQ5364031zbMATH OpenOpenAlexWikidataFDO

Authors Dong Xi, Ekkehard Glimm, Willi Maurer, Frank Bretz

Publication date 2 October 2017

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1605.06397

zbMATH Keywords

adjusted \(p\)-valueclosure principleconsonancecorrelationmultiple test procedurenon-exhaustivenessweighted parametric multiple test procedures

Mathematics Subject Classification ID

Paired and multiple comparisons; multiple testing (62J15) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: We describe a general framework for weighted parametric multiple test procedures based on the closure principle. We utilize general weighting strategies that can reflect complex study objectives and include many procedures in the literature as special cases. The proposed weighted parametric tests bridge the gap between rejection rules using either adjusted significance levels or adjusted $p$-values. This connection is possible by allowing intersection hypotheses to be tested at level smaller than $alpha$, which may be needed for certain study considerations. For such cases we introduce a subclass of exact $alpha$-level parametric tests which satisfy the consonance property. When only subsets of test statistics are correlated, a new procedure is proposed to fully utilize the parametric assumptions within each subset. We illustrate the proposed weighted parametric tests using a clinical trial example.

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Cited in

(15)

• On the optimally weighted z-test for combining probabilities from independent studies
• Graphical approaches for multiple comparison procedures
• Covariate Powered Cross-Weighted Multiple Testing
• Relations among three parametric multiple testing methods for correlated tests
• Sample size optimization and initial allocation of the significance levels in group sequential trials with multiple endpoints
• A unified framework for weighted parametric group sequential design
• Simultaneous confidence regions and weighted hypotheses on parameter arrays
• Symmetric graphs for equally weighted tests, with application to the Hochberg procedure
• Graphical approaches for the control of generalized error rates
• Group sequential Holm and Hochberg procedures
• Optimal weighted Bonferroni tests and their graphical extensions
• Graph based, adaptive, multiarm, multiple endpoint, two-stage designs
• Adjusted inference for multiple testing procedure in group-sequential designs
• Weighted Holm procedures: theory, properties, and recommendations
• Graphical approaches for multiple comparison procedures using weighted Bonferroni, Simes, or parametric tests

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