An Uncertainty Quantification Approach to the Study of Gene Expression Robustness

DOI10.4310/MAA.2021.V28.N2.A5MaRDI QIDQ6327304arXivFDO

Authors Pierre Degond, Shi Jin, Yuhua Zhu

Publication date 16 October 2019

Full work available at URL https://doi.org/10.4310/MAA.2021.V28.N2.A5

Smoothness and regularity of solutions to PDEs (35B65) PDEs in connection with biology, chemistry and other natural sciences (35Q92) PDEs with randomness, stochastic partial differential equations (35R60) Computational methods for stochastic equations (aspects of stochastic analysis) (60H35) Numerical solutions to stochastic differential and integral equations (65C30) Stability and convergence of numerical methods for initial value and initial-boundary value problems involving PDEs (65M12) Spectral, collocation and related methods for initial value and initial-boundary value problems involving PDEs (65M70) Finite element, Rayleigh-Ritz and Galerkin methods for boundary value problems involving PDEs (65N30) Cell biology (92C37) Genetics and epigenetics (92D10)

arXiv classification

cs.NA math.NA

Abstract: We study a chemical kinetic system with uncertainty modeling a gene regulatory network in biology. Specifically, we consider a system of two equations for the messenger RNA and micro RNA content of a cell. Our target is to provide a simple framework for noise buffering in gene expression through micro RNA production. Here the uncertainty, modeled by random variables, enters the system through the initial data and the source term. We obtain a sharp decay rate of the solution to the steady state, which reveals that the biology system is not sensitive to the initial perturbation around the steady state. The sharp regularity estimate leads to the stability of the generalized Polynomial Chaos stochastic Galerkin (gPC-SG) method. Based on the smoothness of the solution in the random space and the stability of the numerical method, we conclude the gPC-SG method has spectral accuracy. Numerical experiments are conducted to verify the theoretical findings.

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