Assessing treatment effect heterogeneity in clinical trials with blocked binary outcomes

DOI10.1002/BIMJ.200510157MaRDI QIDQ5122754zbMATH OpenOpenAlexWikidataFDO

Authors Jeffrey M. Albert, Gary L. Gadbury, Edward J. Mascha

Publication date 24 September 2020

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.200510157

zbMATH Keywords

boundscausal effectscounterfactualspotential outcomesrandomized block designsubject-treatment interaction

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

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• Using secondary outcome to sharpen bounds for treatment harm rate in characterizing heterogeneity
• Estimating treatment effect heterogeneity for binary outcomes via Dirichlet multinomial constraints
• Heterogeneous treatment effects in stratified clinical trials with time‐to‐event endpoints

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