Asymptotic Properties of a General Model of Immune Status

DOI10.1137/21M1466906MaRDI QIDQ6038793zbMATH OpenOpenAlexFDO

Authors Katarzyna Pichór, Ryszard Rudnicki

Publication date 3 May 2023

Published in SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2212.13147

zbMATH Keywords

asymptotic stabilityflow with jumpsimmune statusphysiologically structured populationstochastic semigroup

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) One-parameter semigroups and linear evolution equations (47D06) Applications of operator theory in chemistry and life sciences (47N60) Jump processes on general state spaces (60J76) Epidemiology (92D30)

Abstract: We consider a model of dynamics of the immune system. The model is based on three factors: occasional boosting and continuous waning of immunity and a general description of the period between subsequent boosting events. The antibody concentration changes according to a non-Markovian process. The density of the distribution of this concentration satisfies some partial differential equation with an integral boundary condition. We check that this system generates a stochastic semigroup and we study the long-time behaviour of this semigroup. In particular we prove a theorem on its asymptotic stability.

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Cited in

(3)

• Global analysis of Marczuk's model in case of strong immune system
• With Andrzej Lasota there and back again. The XVII annual lecture dedicated to the memory of Professor Andrzej Lasota
• Long-time behavior of a generalized semi-Markov model of population dynamics

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