autoMR

MaRDI QIDQ7375041CRANFDO

Authors Kelin Zhong, Chia-Ling Kuo

Last update 14 July 2026

Copyright license GNU General Public License, version 3.0

Software version identifier PACKAGES.rds, 0.1.1, 1.0.0, 1.1.0, 1.1.1, 1.1.2, 1.2.0, 1.2.1

Description

Provides tools to summarize, analyze, and visualize results from Mendelian randomization studies using summarized genetic association data. The package includes functions for generating forest plots and scatter plots at the single-nucleotide polymorphism and Mendelian randomization method levels, and for fitting multiple estimators in a unified pipeline, including inverse-variance weighted estimation, Mendelian randomization Egger regression, the weighted median estimator, the robust adjusted profile score, Mendelian randomization pleiotropy residual sum and outlier, Mendelian randomization with the genotype recoding invariance property, and a Bayesian horseshoe method. Related methods are described by Burgess (2013) <doi:10.1002/gepi.21758>, Bowden (2015) <doi:10.1093/ije/dyv080>, Bowden (2016) <doi:10.1002/gepi.21965>, Zhao (2020) <doi:10.1214/19-AOS1866>, Verbanck (2018) <doi:10.1038/s41588-018-0099-7>, Dudbridge (2025) <doi:10.1371/journal.pgen.1011967>, and Grant and Burgess (2024) <doi:10.1016/j.ajhg.2023.12.002>. Related open-source software includes 'TwoSampleMR' <https://github.com/MRCIEU/TwoSampleMR>, 'mr.raps' <https://github.com/qingyuanzhao/mr.raps>, 'MR-PRESSO' <https://github.com/rondolab/MR-PRESSO>, and 'MR-Horse' <https://github.com/aj-grant/mrhorse>.

Cites work

• A Bayesian approach to Mendelian randomization using summary statistics in the univariable and multivariable settings with correlated pleiotropy
• Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
• Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
• Getting to GRIPS with MR-Egger: Modelling directional pleiotropy independently of allele coding
• Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
• Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
• Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score

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