B-scaling: a novel nonparametric data fusion method

DOI10.1214/21-AOAS1537MaRDI QIDQ2170382zbMATH OpenOpenAlexFDO

Authors Yanyan Li

Publication date 5 September 2022

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2109.09940

zbMATH Keywords

data fusiongeneralized eigenvalue problemepigeneticsmultisource data

Mathematics Subject Classification ID

Computational methods for problems pertaining to statistics (62-08) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: Very often for the same scientific question, there may exist different techniques or experiments that measure the same numerical quantity. Historically, various methods have been developed to exploit the information within each type of data independently. However, statistical data fusion methods that could effectively integrate multi-source data under a unified framework are lacking. In this paper, we propose a novel data fusion method, called B-scaling, for integrating multi-source data. Consider $K$ measurements that are generated from different sources but measure the same latent variable through some linear or nonlinear ways. We seek to find a representation of the latent variable, named B-mean, which captures the common information contained in the $K$ measurements while takes into account the nonlinear mappings between them and the latent variable. We also establish the asymptotic property of the B-mean and apply the proposed method to integrate multiple histone modifications and DNA methylation levels for characterizing epigenomic landscape. Both numerical and empirical studies show that B-scaling is a powerful data fusion method with broad applications.

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Cited in

(1)

• A graph theoretical approach to data fusion

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