Basic Principles in Modeling Adaptive Regulation and Immunodominance

DOI10.1007/978-1-4614-4178-6_2MaRDI QIDQ2820373zbMATH OpenOpenAlexFDO

Authors Peter S. Kim, Peter P. Lee, Doron Levy

Publication date 16 September 2016

Published in Lecture Notes on Mathematical Modelling in the Life Sciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/978-1-4614-4178-6_2

zbMATH Keywords

apoptosisdormancyepitopesimmunodominance

Mathematics Subject Classification ID

Physiology (general) (92C30) Medical epidemiology (92C60)

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Cites work

• A theory of immunodominance and adaptive regulation
• Emergent group dynamics governed by regulatory cells produce a robust primary T cell response
• Epitope down-modulation as a mechanism for the coexistence of competing T-cells
• How regulatory CD25+CD4+T cells impinge on tumor immunobiology? On the existence of two alternative dynamical classes of tumors
• Models of CD8+ responses: 1. what is the antigen-independent proliferation program

Cited in

(11)

• Systems biology approaches for understanding cellular mechanisms of immunity in lymph nodes during infection
• Robustness of dengue complex network under targeted versus random attack
• Two-mode network modeling and analysis of dengue epidemic behavior in Gombak, Malaysia
• Modeling LSD1-mediated tumor stagnation
• A Regulatory Principle for Robust Reciprocal-Time Decay of the Adaptive Immune Response
• Modeling the development of cellular exhaustion and tumor-immune stalemate
• Modeling immunodominance in the B-cell response to viral infection
• A theory of immunodominance and adaptive regulation
• Targeting CD4+ T cell exhaustion to improve future immunotherapy strategies
• Epitope down-modulation as a mechanism for the coexistence of competing T-cells
• Immunodominance analysis through interactions of CD8^+ T cells and DCs in lymph nodes

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