Bayesian nonparametric analysis of reversible Markov chains

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Abstract: We introduce a three-parameter random walk with reinforcement, called the scheme, which generalizes the linearly edge reinforced random walk to uncountable spaces. The parameter smoothly tunes the scheme between this edge reinforced random walk and the classical exchangeable two-parameter Hoppe urn scheme, while the parameters alpha and heta modulate how many states are typically visited. Resorting to de Finetti's theorem for Markov chains, we use the scheme to define a nonparametric prior for Bayesian analysis of reversible Markov chains. The prior is applied in Bayesian nonparametric inference for species sampling problems with data generated from a reversible Markov chain with an unknown transition kernel. As a real example, we analyze data from molecular dynamics simulations of protein folding.









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