Bayesian nonparametric inference for quantal response data

DOI10.1214/AOS/1176346511MaRDI QIDQ1064708zbMATH OpenOpenAlexFDO

Authors Larry P. Ammann

Publication date 1984

Published in The Annals of Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1214/aos/1176346511

zbMATH Keywords

binomial samplingDirichlet processfailure ratehazard functionindependent incrementsnonnegative valued stochastic processPosterior Laplace transformsquantal response datasuperposition of two processestolerance distribution

Mathematics Subject Classification ID

Bayesian problems; characterization of Bayes procedures (62C10) Asymptotic distribution theory in statistics (62E20) Bayesian inference (62F15) Nonparametric estimation (62G05) Nonparametric inference (62G99) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Review text

Nonparametric Bayes estimation of the tolerance distribution based on quantal response data is considered with a broad class of priors. If F denotes the distribution function of the tolerance level of an individual to a drug then \(H(t):=-\log (1-F(t))\) is called the hazard function and its derivative is called the failure rate function. In the present paper the hazard function of the tolerance distribution is allowed to be a realization of a nonnegative valued stochastic process with independent increments. This class includes the case when the prior distribution is based on the Dirichlet process. In addition, priors are constructed by taking the failure rate to be the superposition of two processes with independent increments. Posterior Laplace transforms of the corresponding processes are obtained based on quantal response data with binomial sampling. These posterior Laplace transforms are then used to find Bayes estimates, and examples are given to illustrate the results.

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(8)

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• On Bayes inference for a bathtub failure rate via S-paths
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