bfboinet

MaRDI QIDQ7378390CRANFDO

Authors Jing Zhu, Kentaro Takeda, Belay Birlie Yimer

Last update 29 April 2026

Copyright license GNU General Public License, version 3.0

Software version identifier PACKAGES.rds, 0.1.0, 0.2.0, 0.3.0, 0.4.0, 1.0.0, 1.1.0

Description

Implements the Backfill Bayesian Optimal Interval Design (BF-BOIN-ET), a novel clinical trial methodology for dose optimization that simultaneously consider both efficacy and toxicity outcome as described in (Takeda et al (2025) <doi:10.1002/pst.2470>). The package has been extended to include a seamless two-stage phase I/II trial design with backfill and joint efficacy and toxicity monitoring as described in (Takeda et al (2026) <doi:10.1002/pst.70092>).

Cites work

• A Seamless Two‐Stage Phase I/ II Trial Design With Backfill and Joint Monitoring for Dose Optimization
• BF ‐ BOIN ‐ ET : A Backfill Bayesian Optimal Interval Design Using Efficacy and Toxicity Outcomes for Dose Optimization

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