bioclients
Look up genes, variants and proteins from R, without writing a client for every biological web service. Each service gets one client that makes the request and returns a table. Parsing is a separate function that needs no network, so it can run on a saved response and be tested offline. Transport, retries, caching and error handling are left to the 'biohttp' package. Dependencies for single services are optional, so you do not install what you will not use. The services covered include 'Ensembl', described in Dyer et al. (2025) <doi:10.1093/nar/gkae1071>, 'UniProt', in The UniProt Consortium (2025) <doi:10.1093/nar/gkae1010>, 'gnomAD', in Chen et al. (2024) <doi:10.1038/s41586-023-06045-0>, 'Open Targets', in Buniello et al. (2025) <doi:10.1093/nar/gkae1128>, and the 'AlphaFold' Protein Structure Database, in Varadi et al. (2024) <doi:10.1093/nar/gkad1011>. Each client's help page cites the service it calls.
- A genomic mutational constraint map using variation in 76,156 human genomes
- AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences
- Ensembl 2025
- Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery
- UniProt: the Universal Protein Knowledgebase in 2025
This page was built for software: bioclients
