Boolean analysis of lateral inhibition

DOI10.1007/S00285-020-01515-9MaRDI QIDQ2192657zbMATH OpenOpenAlexWikidataFDO

Authors Elisa Tonello, Heike Siebert

Publication date 17 August 2020

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/1904.02544

zbMATH Keywords

Boolean networkspatternscell signallingmulti-cellular systems

Mathematics Subject Classification ID

Systems biology, networks (92C42) General biology and biomathematics (92B05) Graph theory (05C99)

Abstract: We study Boolean networks which are simple spatial models of the highly conserved Delta-Notch system. The models assume the inhibition of Delta in each cell by Notch in the same cell, and the activation of Notch in presence of Delta in surrounding cells. We consider fully asynchronous dynamics over undirected graphs representing the neighbour relation between cells. In this framework, one can show that all attractors are fixed points for the system, independently of the neighbour relation, for instance by using known properties of simplified versions of the models, where only one species per cell is defined. The fixed points correspond to the so-called fine-grained "patterns" that emerge in discrete and continuous modelling of lateral inhibition. We study the reachability of fixed points, giving a characterisation of the trap spaces and the basins of attraction for both the full and the simplified models. In addition, we use a characterisation of the trap spaces to investigate the robustness of patterns to perturbations. The results of this qualitative analysis can complement and guide simulation-based approaches, and serve as a basis for the investigation of more complex mechanisms.

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Cited in

(4)

• Lateral inhibition models of developmental processes
• AND-NOT logic framework for steady state analysis of Boolean network models
• A graph partitioning approach to predicting patterns in lateral inhibition systems
• scientific article; zbMATH DE number 1728647 (Why is no real title available?)

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