Branching processes with resetting as a model for cell division

DOI10.1088/1751-8121/AC491AMaRDI QIDQ5049651zbMATH OpenOpenAlexFDO

Authors Arthur Genthon, Reinaldo García-García, David Lacoste

Publication date 11 November 2022

Published in Journal of Physics A: Mathematical and Theoretical (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2110.15147

zbMATH Keywords

branching processescell divisioncell size controlstochastic resettingstochastic thermodynamics

Mathematics Subject Classification ID

Stochastic methods (Fokker-Planck, Langevin, etc.) applied to problems in time-dependent statistical mechanics (82C31) Population dynamics (general) (92D25)

Abstract: We study the Stochastic Thermodynamics of cell growth and division using a theoretical framework based on branching processes with resetting. Cell division may be split into two sub-processes: branching, by which a given cell gives birth to an identical copy of itself, and resetting, by which some properties of the daughter cells (such as their size or age) are reset to new values following division. We derive the first and second laws of Stochastic Thermodynamics for this process, and identify separate contributions due to branching and resetting. We apply our framework to well-known models of cell size control, such as the sizer, the timer, and the adder. We show that the entropy production of resetting is negative and that of branching is positive for these models in the regime of exponential growth of the colony. This property suggests an analogy between our model for cell growth and division and heat engines, and the introduction of a thermodynamic efficiency, which quantifies the conversion of one form of entropy production to another.

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Cites work

• Stochastic resetting and applications

Cited in

(4)

• scientific article; zbMATH DE number 5657476 (Why is no real title available?)
• Non-equilibrium thermodynamics of diffusion in fluctuating potentials
• Preface: stochastic resetting—theory and applications
• Numerical prediction of the steady-state distribution under stochastic resetting from measurements

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