CB2

MaRDI QIDQ135984CRANFDO

Authors Hyun-hwan Jeong

Last update 29 January 2026

Copyright license MIT license, File License

Software version identifier 1.3.4, 1.0, 1.1, 1.2.1, 1.2.2, 1.3.0, 1.3.1, 1.3.2, 1.3.3, 1.3.6, PACKAGES.rds, 1.3.8

Description

Provides functions for hit gene identification and quantification of sgRNA (single-guided RNA) abundances for CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) pooled screen data analysis. Details are in Jeong et al. (2019) <doi:10.1101/gr.245571.118> and Baggerly et al. (2003) <doi:10.1093/bioinformatics/btg173>.

Cites work

• Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives
• Differential expression in SAGE: accounting for normal between-library variation

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