CML dynamics: Optimal control of age-structured stem cell population

DOI10.1016/J.MATCOM.2010.12.011MaRDI QIDQ554522zbMATH OpenOpenAlexFDO

Authors Chahrazed Benosman, B. Ainseba

Publication date 4 August 2011

Published in Mathematics and Computers in Simulation (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.matcom.2010.12.011

zbMATH Keywords

partial differential equationschronic myeloid leukemiahematopoietic stem cellsdrug therapy

Mathematics Subject Classification ID

Medical applications (general) (92C50) Probabilistic models, generic numerical methods in probability and statistics (65C20) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Applications of optimal control and differential games (49N90)

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Cites work

• scientific article; zbMATH DE number 3806227 (Why is no real title available?)
• A Mathematical Study of the Hematopoiesis Process with Applications to Chronic Myelogenous Leukemia
• A finite difference approximation for a coupled system of nonlinear size-structured populations
• A mathematical model of hematopoiesis. I: Periodic chronic myelogenous leukemia
• Asynchronous exponential growth in an age structured population of proliferating and quiescent cells
• Chemotherapy for tumors: An analysis of the dynamics and a study of quadratic and linear optimal controls
• Epidemics in two competing species
• Numerical integration of a mathematical model of hematopoietic stem cell dynamics
• Optimal Control Applied to Cell-Cycle-Specific Cancer Chemotherapy
• Optimal control for resistance and suboptimal response in CML
• Optimal control of a competitive system with age-structure
• Optimal control of treatment in a mathematical model of chronic myelogenous leukemia
• Optimal controls for a model with pharmacokinetics maximizing bone marrow in cancer chemo\-therapy

Cited in

(6)

• Deterministic and Stochastic Dynamics of Chronic Myelogenous Leukaemia Stem Cells Subject to Hill-Function-Like Signaling
• Feedback mechanisms control coexistence in a stem cell model of acute myeloid leukaemia
• Optimal control of leukemic cell population dynamics
• Hybrid mathematical model of leukemic diseases
• The contribution of age structure to cell population responses to targeted therapeutics
• An ``age-structured model of hematopoietic stem cell organization with application to chronic myeloid leukemia

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