Cellular switches orchestrate rhythmic circuits

DOI10.1007/S00422-018-0778-6MaRDI QIDQ1734639zbMATH OpenOpenAlexDBLPWikidataFDO

Authors Guillaume Drion, Alessio Franci, Rodolphe Sepulchre

Publication date 27 March 2019

Published in Biological Cybernetics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1802.06700

zbMATH Keywords

central pattern generatorsmathematical modelingneuromodulation

Mathematics Subject Classification ID

Biological rhythms and synchronization (92B25) Neural biology (92C20)

Abstract: Small inhibitory neuronal circuits have long been identified as key neuronal motifs to generate and modulate the coexisting rhythms of various motor functions. Our paper highlights the role of a cellular switching mechanism to orchestrate such circuits. The cellular switch makes the circuits reconfigurable, robust, adaptable, and externally controllable. Without this cellular mechanism, the circuits rhythms entirely rely on specific tunings of the synaptic connectivity, which makes them rigid, fragile, and difficult to control externally. We illustrate those properties on the much studied architecture of a small network controlling both the pyloric and gastric rhythms of crabs. The cellular switch is provided by a slow negative conductance often neglected in mathematical modeling of central pattern generators. We propose that this conductance is simple to model and key to computational studies of rhythmic circuit neuromodulation.

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Cites work

• An organizing center in a planar model of neuronal excitability
• Modeling the modulation of neuronal bursting: a singularity theory approach
• Robust modulation of integrate-and-fire models

Cited in

(4)

• Control theory in biology and medicine. Introduction to the special issue
• Simulating small neural circuits with a discrete computational model
• scientific article; zbMATH DE number 5529980 (Why is no real title available?)
• Single circuit in V1 capable of switching contexts during movement using an inhibitory population as a switch

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