ComBatFamQC
Provides a comprehensive framework for batch effect diagnostics, harmonization, and post-harmonization downstream analysis. Features include interactive visualization tools, robust statistical tests, and a range of harmonization techniques. Additionally, 'ComBatFamQC' enables the creation of life-span age trend plots with estimated age-adjusted centiles and facilitates the generation of covariate-corrected residuals for analytical purposes. Methods for harmonization are based on approaches described in Johnson et al., (2007) <doi:10.1093/biostatistics/kxj037>, Beer et al., (2020) <doi:10.1016/j.neuroimage.2020.117129>, Pomponio et al., (2020) <doi:10.1016/j.neuroimage.2019.116450>, and Chen et al., (2021) <doi:10.1002/hbm.25688>.
- Adjusting batch effects in microarray expression data using empirical Bayes methods
- Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan
- Longitudinal ComBat: A method for harmonizing longitudinal multi-scanner imaging data
- Mitigating site effects in covariance for machine learning in neuroimaging data
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