Compartmental analysis of dynamic nuclear medicine data: regularization procedure and application to physiology

DOI10.1080/17415977.2018.1512603MaRDI QIDQ4990744zbMATH OpenOpenAlexFDO

Authors Fabrice Delbary, Sara Garbarino

Publication date 31 May 2021

Published in Inverse Problems in Science and Engineering (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1608.01825

zbMATH Keywords

compartmental analysisGauss-Newton methodnuclear medicine data

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biomedical imaging and signal processing (92C55)

Abstract: Compartmental models based on tracer mass balance are extensively used in clinical and pre-clinical nuclear medicine in order to obtain quantitative information on tracer metabolism in the biological tissue. This paper is the second of a series of two that deal with the problem of tracer coefficient estimation via compartmental modelling in an inverse problem framework. While the previous work was devoted to the discussion of identifiability issues for 2, 3 and n-dimension compartmental systems, here we discuss the problem of numerically determining the tracer coefficients by means of a general regularized Multivariate Gauss Newton scheme. In this paper, applications concerning cerebral, hepatic and renal functions are considered, involving experimental measurements on FDG-PET data on different set of murine models.

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Cites work

• A physiology-based parametric imaging method for FDG-PET data
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• scientific article; zbMATH DE number 936298 (Why is no real title available?)
• scientific article; zbMATH DE number 5060482 (Why is no real title available?)

Cited in

(12)

• Estimate of FDG excretion by means of compartmental analysis and ant colony optimization of nuclear medicine data
• Multivariate regularized Newton and Levenberg-Marquardt methods: a comparison on synthetic data of tumor hypoxia in a kinetic framework
• Mathematical modeling of kinetics of iodine-containing radiotracers in nuclear medicine problems
• Compartmental analysis of dynamic nuclear medicine data: models and identifiability
• Global Compartmental Pharmacokinetic Models for Spatiotemporal SPECT and PET Imaging
• scientific article; zbMATH DE number 3926690 (Why is no real title available?)
• A physiology-based parametric imaging method for FDG-PET data
• Parameter identification in medical imaging
• Regularized estimation and model selection in compartment models
• Nonparametric residue analysis of dynamic PET data with application to cerebral FDG studies in normals
• Computational Science and Its Applications – ICCSA 2004
• Exact parameter identification in PET pharmacokinetic modeling: extension to the reversible two tissue compartment model

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