Control of a model of DNA division via parametric resonance

DOI10.1063/1.4790835MaRDI QIDQ2944680zbMATH OpenOpenAlexWikidataFDO

Authors Houman Owhadi, Molei Tao, Tomohiro Yanao, Wang Sang Koon

Publication date 2 September 2015

Published in Chaos: An Interdisciplinary Journal of Nonlinear Science (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1211.4064, https://resolver.caltech.edu/CaltechAUTHORS:20130502-133827036

Mathematics Subject Classification ID

Protein sequences, DNA sequences (92D20)

Abstract: We study the internal resonance, energy transfer, activation mechanism, and control of a model of DNA division via parametric resonance. While the system is robust to noise, this study shows that it is sensitive to specific fine scale modes and frequencies that could be targeted by low intensity electro-magnetic fields for triggering and controlling the division. The DNA model is a chain of pendula in a Morse potential. While the (possibly parametrically excited) system has a large number of degrees of freedom and a large number of intrinsic time scales, global and slow variables can be identified by (i) first reducing its dynamic to two modes exchanging energy between each other and (ii) averaging the dynamic of the reduced system with respect to the phase of the fastest mode. Surprisingly the global and slow dynamic of the system remains Hamiltonian (despite the parametric excitation) and the study of its associated effective potential shows how parametric excitation can turn the unstable open state into a stable one. Numerical experiments support the accuracy of the time-averaged reduced Hamiltonian in capturing the global and slow dynamic of the full system.

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Cited in

(8)

• Simply improved averaging for coupled oscillators and weakly nonlinear waves
• Parametric resonance in DNA
• Temporal homogenization of linear ODEs, with applications to parametric super-resonance and energy harvest
• Parametric resonance in a mesoscopic discrete DNA model
• Parametric resonance for enhancing the rate of metastable transition
• The 0:1 resonance bifurcation associated with the supercritical Hamiltonian pitchfork bifurcation
• Small-noise-induced metastable transition of periodically perturbed systems
• Can specific THz fields induce collective base-flipping in DNA? A stochastic averaging and resonant enhancement investigation based on a new mesoscopic model

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