DNA sequence from the unzipping force? One mutation problem

DOI10.1088/0305-4470/35/26/101MaRDI QIDQ4465884zbMATH OpenOpenAlexFDO

Authors Somendra M. Bhattacharjee, Davide Marenduzzo

Publication date 9 June 2004

Published in Journal of Physics A: Mathematical and General (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/cond-mat/0106110

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Problems related to evolution (92D15) Protein sequences, DNA sequences (92D20)

Abstract: The possibility of detecting mutations in a DNA from force measurements (as a first step towards sequence analysis) is discussed theoretically based on exact calculations. The force signal is associated with the domain wall separating the zipped from the unzipped regions. We propose a comparison method (``differential force microscope) to detect mutations. Two lattice models are treated as specific examples.

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