Pharmacological dataset on drug-induced TdP risk assessment
DOI10.5281/zenodo.8058964Zenodo8058964MaRDI QIDQ4834866
Dataset published at Zenodo repository
Publication date: 20 June 2023
Copyright license: Creative Commons Attribution 4.0 International
Community: Graphical Modelling and Causal Inference
A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset defines 4 torsade de pointes (TdP) risk categories in the parameter "class" . For each of 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained. Detailed description follows. A dash in the dataset means that no value was found publicly available, thus it was considered that the drug effect on that current was negligible. The dataset can be used (and is important) while studing causal discovery methods to infer ion channels selection for the drug-induced TdP risk.
