Drug-Induced TdP Risk Assessment

DOI10.5281/ZENODO.8058964Zenodo8058964MaRDI QIDQ4834866FDOQ4834866

Dataset in the Graphical Modelling and Causal Inference Zenodo Community

MaRDI

Publication date: 27 July 2020

Copyright license: Creative Commons Attribution 4.0 International

Community: Graphical Modelling and Causal Inference

Description

A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset provides 4 torsade de pointes (TdP) risk categories.  For all 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained (Llopis-Lorente et al., 2020).

Cites work

• In Silico Classifiers for the Assessment of Drug Proarrhythmicity

Cited In (1)

• In Silico Classifiers for the Assessment of Drug Proarrhythmicity

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