Plasma circulating microRNA-expression quantitative trait loci (eQTLs) data in the Rotterdam Study

DOI10.5281/zenodo.13869398Zenodo13869398MaRDI QIDQ6683820FDOQ6683820

Dataset published at Zenodo repository.

Mohsen Ghanbari

Publication date: 1 October 2024

Copyright license: Creative Commons Attribution 4.0 International

Description

The dataset contains GWAS summary statistics for 2,083 plasma circulating microRNAs, obtained from nearly 2,178 participants of the Rotterdam Study.The dataset includes three files, as outlined below: File1: SNP_reference_file_maf0.01_Rsq0.7.txt A reference file for SNPs with good imputation quality (Rsq 0.7) and minor allele frequency 0.01 among participants included in our GWAS in the Rotterdam Study (N=2,178). The headers are: SNP: rsID chr: chromosome number according to GRCh37 bp: basepair position according to GRCh37 effect_allele: effect allele other_allele: other allele eaf: effect allele frequency File2: miReQTLs_1e-5_maf0.01_Rsq0.7.txt Summary statistics for all SNPs significantly associated with 2083 miRNAs (p-value 1e-5), filtered by minor allele frequency 0.01 and Rsq 0.7. The headers are: SNP: rsID beta: effect estimate se: standard error pval: p-value miRNA: miRNA ID File3: miReQTLs_nominal_sig.csv.gz Summary statistics for all SNPs nominally associated with 2083 miRNAs (p-value 0.05). The headers are: RSID: SNP ID p-value: p-value phenotype: miRNA SE: standard error BETA: effect estimate The SNP allelic information and frequency can be found in the reference file (File1). For more information, please contact: m.ghanbari@erasmusmc.nl

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