Dataset used for "Somatic hypermutation analysis for improved identification of B cell clonal families from next-generation sequencing data"
DOI10.5281/zenodo.3775457Zenodo3775457MaRDI QIDQ6684743FDOQ6684743
Dataset published at Zenodo repository.
Steven H. Kleinstein, Nima Nouri
Publication date: 29 April 2020
Copyright license: Creative Commons Attribution 4.0 International
Each simulated dataset was generated using the AbSim R package (version 0.2.6) in a B cell single-lineage fashion. Each B cell clone simulation begins with a random selection from sets of IGHV, IGHD, and IGHJ germline sequences to produce a unique V(D)J recombination event. Then, clones are made by introducing mutations using a local nucleotide context-dependent model (S5F model) along a phylogenetic tree in which branching events occur stochastically.
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