Human lung cancer harbors spatially-organized stem-immunity hubs that associate with response to immunotherapy

DOI10.5281/zenodo.11198494Zenodo11198494MaRDI QIDQ6686870FDOQ6686870

Dataset published at Zenodo repository.

Nir Hacohen, Jonathan Chen, Ilya Korsunsky, Justin Gainor

Publication date: 15 February 2024

Copyright license: Creative Commons Attribution 4.0 International

Description

Data associated with Chen, Nieman, Spurrell et al "Human lung cancer harbors spatially-organized stem-immunity hubs that associate with response to immunotherapy" Nature Immunology, 2024. (1) Multiplex RNA scope. Processed cell-level data from 3 datasets, separated into manually selected "Stem Immunity" regions and "Tumor" regions, in separate files. (2) GeoMx. Unprocessed GeoMex data, with standard fields provided by Nanostring software. (3) MERFISH. Transcript-level information, including CellPose and Baysor segmentation. (4) Co-registered multispectral RNA and protein images. Processed cell-level data from 46 patients. Patient-level meta data information is available in supplementary table 1, tab B_Patient_Metadata. Fluorophore channel information is Figure 1a. Paper:https://www.nature.com/articles/s41590-024-01792-2

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