Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma
DOI10.5281/zenodo.10076517Zenodo10076517MaRDI QIDQ6690023FDOQ6690023
Dataset published at Zenodo repository.
Hiroshi Hyakusoku, Richard Lewis, Konstantina Stankovic, Lukas Landegger, Alyssa Brown, Takeshi Fujita, Sasa Vasilijic, Yin Ren, D. Bradley Welling, Nadia Atai, Charvi Malhotra, Steven Worthington, Mehmet Sahin, Rohan Reddy, Jessica Sagers
Publication date: 6 November 2023
Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells, and typically presenting with hearing loss. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the auditory nerve, does not explain the common clinical finding that patients with small tumors can have profound hearing loss, suggesting that tumor-secreted factors could influence hearing ability in VS patients. We conducted profiling of patients' plasma for 66 immune-related factors in patients with sporadic VS (N170) and identified and validated candidate biomarkers associated with tumor size (S100B) and hearing (MCP-3). We further identified a 9-biomarker panel (TNR-R2, MIF, CD30, MCP-3, IL-2R, BLC, TWEAK, eotaxin, S100B) with outstanding discriminatory ability for VS. These findings revealed possible therapeutic targets for VS, providing a unique diagnostic tool that may predict hearing change and tumor growth in VS patients, and may inform the timing of tumor resection to preserve hearing.
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