Analysis of human humoral responses in a typhoid vaccine efficacy trial used for SIMON analysis
The VAST dataset contains data from 72 individuals enrolled in the clinical study to evaluate humoral responses in a typhoid vaccine efficacy trial in a controlled human Salmonella Typhi infection model (see original publication: https://doi.org/10.3389/fimmu.2019.02582). Only day 0 (day of the challenge) log-transformed data were used in the SIMON analysis, as described in the publication (https://doi.org/10.1101/2020.08.16.252767). Individuals were vaccinated with either a purified Vi polysaccharide (Vi-PS) vaccine (35 individuals) or the Vi tetanus toxoid conjugate (Vi-TT) vaccine (37 individuals) one month prior to oral challenge with live Salmonella Typhi. Out of 72 individuals, 26 developed an acute typhoid infection following the challenge.
This page was built for dataset: Analysis of human humoral responses in a typhoid vaccine efficacy trial used for SIMON analysis
