Multilevel irreversibility reveals higher-order organisation of non-equilibrium interactions in human brain dynamics
DOI10.5281/zenodo.13939016Zenodo13939016MaRDI QIDQ6696002FDOQ6696002
Dataset published at Zenodo repository.
Gustavo Deco, Peter Vuust, Morten L Kringelbach, Renaud Lambiotte, Gemma Fernandez-Rubio, Alain Goriely, Ramón Nartallo-Kaluarachchi, Leonardo Bonetti
Publication date: 16 October 2024
Copyright license: Creative Commons Attribution 4.0 International
This dataset is used in the paper: R.Nartallo-Kaluarachchi et al. Multilevel irreversibility reveals higher-order organisation of non-equilibrium interactions in human brain dynamics The code for the analysis of the MEG data is made available at https://github.com/rnartallo/multilevelirreversibility The in-house code used for MEG pre-processing is available at https://github.com/leonardob92/LBPD-1.0. The data is provided after pre-processing (Maxfilter, ICA for removing eye blink and heart beat, co-registration with the individual MRI T1) and epoching. This dataset contains data for 51 participants with 15 trials per participant. The data is provided as the MEG_DataRNK2024.mat file which contains a nested MATLAB structure MEG_Data: 1 x 51 Cell: Cell: 6 x 1024 x 15 Double This represent the activity from 6 brain regions at 1024 time-points for 15 trials. Abstract Information processing in the human brain can be modelled as a complex dynamical system operating out of equilibrium with multiple regions interacting nonlinearly. Yet, despite extensive study of the global level of non-equilibrium in the brain, quantifying the irreversibility of interactions among brain regions at multiple levels remains an unresolved challenge. Here, we present the Directed Multiplex Visibility Graph Irreversibility framework, a method for analysing neural recordings using network analysis of time-series. Our approach constructs directed multi-layer graphs from multivariate time-series where information about irreversibility can be decoded from the marginal degree distributions across the layers, which each represents a variable. This framework is able to quantify the irreversibility of every interaction in the complex system. Applying the method to magnetoencephalography recordings during a long-term memory recognition task, we quantify the multivariate irreversibility of interactions between brain regions and identify the combinations of regions which showed higher levels of non-equilibrium in their interactions. For individual regions, we find higher irreversibility in cognitive versus sensorial brain regions whilst for pairs, strong relationships are uncovered between cognitive and sensorial pairs in the same hemisphere. For triplets and quadruplets, the most non-equilibrium interactions are between cognitive-sensorial pairs alongside medial regions. Finally, for quintuplets, our analysis finds higher irreversibility when the prefrontal cortex is included in the interaction. Combining these results, we show that multilevel irreversibility offers unique insights into the higher-order, hierarchical organisation of neural dynamics and presents a new perspective on the analysis of brain network dynamics.
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