All simulation results, figures and code regarding the manuscript: Calibrating models of cancer invasion: parameter estimation using Approximate Bayesian Computation and gradient matching

DOI10.5281/zenodo.4341899Zenodo4341899MaRDI QIDQ6698257FDOQ6698257

Dataset published at Zenodo repository.

M. A. J. Chaplain, Yunchen Xiao, Len Thomas

Publication date: 26 March 2021

Description

We present two different methods to estimate parameters within a partial differential equation (PDE) model of cancer invasion. The model describes the spatio-temporal evolution of three variables -- tumour cell density, extracellular matrix density and matrix degrading enzyme concentration -- in a one-dimensional tissue domain. The first method is a likelihood-free approach associated with Approximate Bayesian Computation (ABC); the second is a two-stage gradient matching method based on smoothing the data with a Generalized Additive Model (GAM) and matching gradients from the GAM to those from the model. Both methods performed well on simulated data.  To increase realism, additionally we tested the gradient matching scheme with simulated measurement error and found that the ability to estimate some model parameters deteriorated rapidly as measurement error increased.

This page was built for dataset: All simulation results, figures and code regarding the manuscript: Calibrating models of cancer invasion: parameter estimation using Approximate Bayesian Computation and gradient matching