Genetic control of collective behavior in zebrafish
DOI10.5281/zenodo.5089627Zenodo5089627MaRDI QIDQ6700559FDOQ6700559
Dataset published at Zenodo repository.
Katherine Conen, Mark Fishman, Peixin Zhu, Gregory Molind, Matthew Coble, Wenlong Tang, Caroline Fawcett, Tingwei Tsai, Guoqiang Zhang, Jacob Davidson, Ellen Sanchez, Jingyao Li, Xiaorui Xiong, Fabrizio Serluca, Iain D. Couzin, Jian Fang
Publication date: 20 February 2020
Many animals, including humans, have evolved to live and move in groups. In humans, disrupted social interactions are a fundamental feature of many psychiatric disorders. However, we know little about how genes regulate social behavior. Zebrafish may serve as a powerful model to explore this question. By comparing the behavior of wild-type fish to 90 genetic lines, we show that mutations of genes associated with human psychiatric disorders can alter the collective behavior of adult zebrafish. We identify three categories of behavioral variation across mutants: "scattered", in which fish show reduced cohesion; "coordinated", in which fish swim more in aligned schools; and "huddled", in which fish form dense but disordered groups. Changes in individual interaction rules can explain these differences. This work demonstrates how emergent patterns in animal groups can be altered by genetic changes in individuals, and establishes a framework for understanding the fundamentals of social information processing.
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