Adult neurogenesis improves spatial information encoding in the mouse hippocampus - hM4Di Silencing
DOI10.5281/zenodo.10913386Zenodo10913386MaRDI QIDQ6707026FDOQ6707026
Dataset published at Zenodo repository.
M. Agustina Frechou, Evan A. Huaman, Sunaina S Martin, Wolfgang Tomé, Ruben Coen-Cagli, J. Tiago Gonçalves, Kelsey McDermott, Solen Gokhan
Publication date: 3 April 2024
In vivo two-photon imaging dataset for Frechou et al. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus" This dataset includes data from CNO-induced chemogenetic silencing experiments in hM4Di+ and hM4Di-(control) mice. There is another Zenodo dataset with the remaining hM4Di-(control) mice here. The folder for each mouse includes baseline (pre) and post-CNO (cno) recordings. For each recording we included raw imaging data consisting of: Individual frames (.tif files) from 3 consecutive 3 min Ca2+ imaging movies (which were concatenated for analysis) Microscope settings metadata (Experiment.xml) Mouse location data (Episode001.h5 in SyncData folder) containing rotary encoder and RFID data Some analyzed data is also included: Suite2p analysis data (Suite2p folder) fluorescence.npycontains raw fluorescence data (the F output of Suite2p data extraction). Rows are individual cells and columns are frames (i.e. timepoints) acquired at 15.253 Hz. positions.npycontains the position of the mouse on the treadmill belt indexed from 0 to 100. Both NumPy(.npy) files are the output of the Preprocessing.py code, part of the analysis pipeline used for data analysis in the original publication, which can be found at https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis Refer to the original publication for additional information. The sex of individual mice is as follows: Group Mouse # Sex Group Mouse # Sex hM4Di+ M1 M hM4Di- M1 M M2 M M2 M M3 F M3 M M4 F M5 M M6 M M7 M M8 F M9 F
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