Kinetics of selected blood biomarkers of articular cartilage in response to stress test with modulated ambulatory load
DOI10.5281/zenodo.4955982Zenodo4955982MaRDI QIDQ6709044FDOQ6709044
Dataset published at Zenodo repository.
Christian Egloff, Annegret Mündermann, Werner Vach, Simon Herger
Publication date: 8 June 2021
Copyright license: Creative Commons Attribution 4.0 International
The goal of this work was todetermine the suitability of selected blood biomarkers of articular cartilage as mechanosensitive markers and to investigate the dose-response relationship between ambulatory load magnitude and marker kinetics in response to load. Serum samples were collected from 24 healthy volunteers before (0) and at three time points (1=0min; 2=30min; 3=60min)after a 30-minute walking stress test performed on a treadmill on three test days.In each experimental session, one of three ambulatory loads was applied: 100% body weight (BW); 80%BW; 120%BW. Serum concentrations of COMP, MMP-3, MMP-9, ADAMTS-4, PRG-4, CPII, C2C and IL-6 were assessed using commercial enzyme-linked immunosorbent assays. ADAMTS -A disintegrin and metalloproteinase with thrombospondin motifs C2C -COL23/4Clong mono epitope COMP - cartilage oligomeric matrix protein CPII -C-propeptide is removed from the procollagen extracellularly and directly reflects the rate of type II procollagen synthesis IL - interleukin MMP - matrix metalloproteinasis PRG - proteoglycan The file contains the raw concentrations for each marker, participant, time point and condition.
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