Lipidomics for diagnosis and prognosis of pulmonary hypertension
DOI10.5281/zenodo.7857706Zenodo7857706MaRDI QIDQ6715959FDOQ6715959
Dataset published at Zenodo repository.
Ulrich Bodenhofer, Thomas Pieber, Andrea Olschewski, Elmar Zügner, Natalie Bordag, Bradley A. Maron, Vasile Foris, Valentina Biasin, Bence Miklos Nagy, Helga Ludwig, Christoph Magnes, Silvia Ulrich, Tobias Lange, Konrad Hötzenecker, Chandran Nagaraj, Horst Olschewski
Publication date: 24 April 2023
Copyright license: Creative Commons Attribution 4.0 International
Pulmonary hypertension (PH) is associated with high morbidity and mortality with an urgent need for diagnostic and prognostic biomarkers. A training cohort of PH patients, disease controls without PH, and healthy controls was investigated using metabolomics and machine learning. Specific free fatty acid (FFA)/lipid-ratio biomarkers were diagnostic and predictive for PH survival with an area under the curve (AUC) of 0.89. FFA/lipid-ratio performance was independently validated in PH patients from other centers(AUC 0.90). Survival could be predicted in an age-independent manner and a combination with established clinical scores (FPHR4p, COMPERA 2.0) increased the scores hazard risk. Our mechanistic studies in healthy and diseased pulmonary artery endothelial and smooth muscle cells indicate a functional involvement of increased FFA levels in pathophysiology of PH. In conclusion, lipidomic changes in PH can be used as a novel diagnostic and prognostic approach and may help the discovery of new therapeutic targets.
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