An integrated polygenic tool substantially enhances coronary artery disease prediction
DOI10.5281/zenodo.4421038Zenodo4421038MaRDI QIDQ6716358FDOQ6716358
Dataset published at Zenodo repository.
Michael Sivley, Chris C. A. Spencer, Peter Sørensen, Peter Donnelly, Vincent Plagnol, Eva Krapohl, Michael E. Weale, Jonathan A. Griffiths, Ayden Saffari, Alexander S. Lachapelle, Saskia Selzam, Rachel Moore, William A. Tarran, Fernando Riveros-McKay
Publication date: 6 January 2021
Copyright license: Creative Commons Attribution 4.0 International
Summary-level CAD GWAS data generated by Genomics plc as presented in: Riveros-Mckay F. et al. An integrated polygenic tool substantially enhances coronary artery disease prediction. Circulation: Genomics and Precision Medicine (in press). If you have any questions or comments regarding these files, please contact Genomics plc at research@genomicsplc.com NOTES ----------------------------- These analyses were carried out using the full UK Biobank imputation data release (v3b). Analyses were restricted to a subset of UK Biobank, described as Group I in the published paper. Group I, no PCE/QRISK3 available, included 114,196 European-ancestry individuals with missing data that prevented PCE or QRISK3 calculation. CAD case phenotypes were defined as described in the Phenotype definitions section of the papers Supplementary Materials, using both prevalent (pre-baseline) and incident (post-baseline) events. All analyses included Age at assessment, sex, genotyping chip, and 10 principal components as covariates. We used plink2.0 logistic regression. For chromosome X variants males were treated as having 0 or 2 alternative alleles. The results are not adjusted for genomic control. DATA FILE CONTENT DESCRIPTION ----------------------------- cpra Variant ID in CPRA format. Position reflects position in b37. chrom Chromosome pos Position in base pairs (b37, 1-based) alt Alternative allele (effect allele) beta Effect size (log odds ratio) standard_error Standard error of beta minus_log10_p Minus log(base 10) of P-value ref Reference allele (non-effect allele) ncase Number of cases ncontrol Number of controls
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