A comprehensive experimental analysis of the local passive response across the healthy porcine left ventricle
DOI10.5281/zenodo.12706383Zenodo12706383MaRDI QIDQ6722049FDOQ6722049
Dataset published at Zenodo repository.
Alba Pérez-Martínez, Aida Oliván-Viguera, Nicolás Laita, M. A. Martínez, Alejandro Aparici-Gil, Manuel Doblaré, Estefania Peña
Publication date: 10 July 2024
Copyright license: Creative Commons Attribution 4.0 International
This work provides a comprehensive characterization of porcine myocardial tissue, combining biaxial (Bx), simple triaxial shear (STS) and confined compression (CC) tests to analyze its elastic behavior under cyclic loads. We expanded this study to different zones of the ventricular free wall, providing insights into the local behavior along the longitudinal and radial coordinates. The aging impact was also assessed by comparing two age groups (4 and 8 months). Resulting data showed that the myocardium exhibits a highly nonlinear hyperelastic and incompressible behavior. We observed an anisotropy ratio of 2-2.4 between averaged peak stresses in Bx tests and 1-0.59-0.41 orthotropy ratios for normalised fiber-sheet-normal peak stresses in STS tests. We obtained a highly incompressible response, reaching volumetric pressures of 2-7 MPa for perfused tissue in CC tests, with notable differences when fluid drainage was allowed, suggesting a high permeability. Regional analysis showed reduced stiffness and anisotropy (20-25%) at the apical region compared to the medial, which we attributed to differences in the fiber field dispersion. Compressibility also increased towards the epicardium and apical regions. Regarding age-related variations, 8-month animals showed stiffer response (at least 30% increase), particularly in directions where the mechanical stress is absorbed by collagenous fibers (more than 90%), as supported by a histological analysis. Although compressibility of perfused tissue remained unchanged, permeability significantly reduced in 8-month-old animals. Our findings offer new insights into myocardial properties, emphasizing on local variations, which can help to get a more realistic understanding of cardiac mechanics in this common animal model.
This page was built for dataset: A comprehensive experimental analysis of the local passive response across the healthy porcine left ventricle
