A putative origin of the insect chemosensory receptor superfamily in the last common eukaryotic ancestor

DOI10.5281/zenodo.4360411Zenodo4360411MaRDI QIDQ6726183FDOQ6726183

Dataset published at Zenodo repository.

Christophe Dessimoz, David Moi, Richard Benton

Publication date: 17 December 2020

Description

The insect chemosensory repertoires of Odorant Receptors (ORs) and Gustatory Receptors (GRs) together represent one of the largest families of ligand-gated ion channels. Previous analyses have identified homologous 'Gustatory Receptor-Like (GRL)' proteins across Animalia, but the evolutionary origin of this novel class of ion channels is unknown. We describe a survey of unicellular eukaryotic genomes for GRLs, identifying several candidates in fungi, protists and algae that contain many structural features characteristic of animal GRLs. The existence of these proteins in unicellular eukaryotes, together with ab initio protein structure predictions, provide evidence for homology between GRLs and a family of uncharacterized plant proteins containing the DUF3537 domain. Together, our analyses suggest an origin of this protein superfamily in the last common eukaryotic ancestor.

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