depower

MaRDI QIDQ7381025CRANFDO

Authors Brett Klamer, Lianbo Yu

Last update 30 January 2026

Copyright license MIT license, File License

Software version identifier PACKAGES.rds, 2024.12.4, 2025.1.20, 2025.10.21, 2026.1.30

Description

Provides a convenient framework to simulate, test, power, and visualize data for differential expression studies with lognormal or negative binomial outcomes. Supported designs are two-sample comparisons of independent or dependent outcomes. Power may be summarized in the context of controlling the per-family error rate or family-wise error rate. Negative binomial methods are described in Yu, Fernandez, and Brock (2017) <doi:10.1186/s12859-017-1648-2> and Yu, Fernandez, and Brock (2020) <doi:10.1186/s12859-020-3541-7>.

Cites work

• Power analysis for RNA-Seq differential expression studies
• Power analysis for RNA-Seq differential expression studies using generalized linear mixed effects models

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