Detection of spatial clustering with average likelihood ratio test statistics
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Abstract: Generalized likelihood ratio (GLR) test statistics are often used in the detection of spatial clustering in case-control and case-population datasets to check for a significantly large proportion of cases within some scanning window. The traditional spatial scan test statistic takes the supremum GLR value over all windows, whereas the average likelihood ratio (ALR) test statistic that we consider here takes an average of the GLR values. Numerical experiments in the literature and in this paper show that the ALR test statistic has more power compared to the spatial scan statistic. We develop in this paper accurate tail probability approximations of the ALR test statistic that allow us to by-pass computer intensive Monte Carlo procedures to estimate -values. In models that adjust for covariates, these Monte Carlo evaluations require an initial fitting of parameters that can result in very biased -value estimates.
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Cited in
(16)- On the limiting distribution of the spatial scan statistic
- Discussion on “Change-Points: From Sequential Detection to Biology and Back” by David Siegmund
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- Asymptotic Distribution of Score Statistics for Spatial Cluster Detection with Censored Data
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- An Alternative Cluster Detection Test in Spatial Scan Statistics
- Identifying the support of rectangular signals in Gaussian noise
- Optimal inference with a multidimensional multiscale statistic
- Spatial Cluster Detection for Censored Outcome Data
- Optimal detection of a jump in the intensity of a Poisson process or in a density with likelihood ratio statistics
- Generalized scan statistics for disease surveillance
- A combined SR-CUSUM procedure for detecting common changes in panel data
- Spatial Event Cluster Detection Using a Compound Poisson Distribution
- Large-scale inference with block structure
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