Efficient Estimation of Optimal Regimes Under a No Direct Effect Assumption

DOI10.1080/01621459.2020.1856117MaRDI QIDQ5857144zbMATH OpenOpenAlexWikidataFDO

Authors Lin Liu, Zach Shahn, James Robins, Andrea Rotnitzky

Publication date 30 March 2021

Published in Journal of the American Statistical Association (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/1908.10448

zbMATH Keywords

direct effectsnuisance tangent spaceoptimal dynamic regimesoptimal regime structural nested mean modelsscreening

Mathematics Subject Classification ID

Point estimation (62F10) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: We derive new estimators of an optimal joint testing and treatment regime under the no direct effect (NDE) assumption that a given laboratory, diagnostic, or screening test has no effect on a patient's clinical outcomes except through the effect of the test results on the choice of treatment. We model the optimal joint strategy using an optimal regime structural nested mean model (opt-SNMM). The proposed estimators are more efficient than previous estimators of the parameters of an opt-SNMM because they efficiently leverage the `no direct effect (NDE) of testing' assumption. Our methods will be of importance to decision scientists who either perform cost-benefit analyses or are tasked with the estimation of the `value of information' supplied by an expensive diagnostic test (such as an MRI to screen for lung cancer).

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Cited in

(3)

• On testing conditional qualitative treatment effects
• Demystifying Statistical Learning Based on Efficient Influence Functions
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