Explaining high alloreactivity as a quantitative consequence of affinity-driven thymocyte selection

DOI10.1073/PNAS.96.9.5153MaRDI QIDQ4261057zbMATH OpenOpenAlexWikidataFDO

Authors Vincent Detours, Alan S. Perelson

Publication date 1 September 1999

Published in Proceedings of the National Academy of Sciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1073/pnas.96.9.5153

zbMATH Keywords

affinity modelalloreactivityT cell selection

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

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Cited in

(9)

• Broad cross-reactivity of the T-cell repertoire achieves specific and sufficiently rapid target searching
• The effects of affinity mediated clonal expansion of premigrant thymocytes on the periphery T-cell repertoire
• Dynamics of T cell receptor distributions following acute thymic atrophy and resumption
• Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy
• Foreignness as a matter of degree: the relative immunogenicity of peptide/MHC ligands
• Quantifying the strength of ligand antagonism in TCR triggering
• Generation of the natural killer cell repertoire: the sequential vs. the two-step selection model
• Thymic Presentation of Autoantigens and the Efficiency of Negative Selection
• The influence of T cell development on pathogen specificity and autoreactivity

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