Flexible estimation in cure survival models using Bayesian P-splines
From MaRDI portal
Abstract: In the analysis of survival data, it is usually assumed that any unit will experience the event of interest if it is observed for a sufficient long time. However, one can explicitly assume that an unknown proportion of the population under study will never experience the monitored event. The promotion time model, which has a biological motivation, is one of the survival models taking this feature into account. The promotion time model assumes that the failure time of each subject is generated by the minimum of N latent event times which are independent with a common distribution independent of N. We propose an extension which allows the covariates to influence simultaneously the probability of being cured and the latent distribution. We estimate the latent distribution using a flexible Cox proportional hazard model where the logarithm of the baseline hazard function is specified using Bayesian P-splines. Introducing covariates in the latent distribution implies that the population hazard function might not have a proportional hazard structure. However, the use of the P-splines provides a smooth estimation of the population hazard ratio over time. We propose a restricted use of the model when the follow up of the study is not sufficiently long. A simulation study evaluating the accuracy of our methodology is presented. The proposed model is illustrated on data from the phase III Melanoma e1684 clinical trial.
Recommendations
- A flexible model for survival data with a cure rate: a Bayesian approach
- On an extension of the promotion time cure model
- Bayesian dynamic models for survival data with a cure fraction
- Estimation and identification issues in the promotion time cure model when the same covariates influence long- and short-term survival
- Cure rate models: A unified approach
Cites work
- scientific article; zbMATH DE number 5711158 (Why is no real title available?)
- scientific article; zbMATH DE number 1249696 (Why is no real title available?)
- A New Bayesian Model for Survival Data with a Surviving Fraction
- A Nonparametric Mixture Model for Cure Rate Estimation
- A Proportional Hazards Model Taking Account of Long-Term Survivors
- A mixture model combining logistic regression with proportional hazards regression
- A new semiparametric estimation method for accelerated hazards mixture cure model
- A semiparametric regression cure model for interval-censored data
- An adaptive Metropolis algorithm
- Archimedean copula estimation using Bayesian splines smoothing techniques
- Bayesian semiparametric models for survival data with a cure fraction
- Cure Rate Model With Mismeasured Covariates Under Transformation
- Cure rate models: A unified approach
- Estimating baseline distribution in proportional hazards cure models
- Estimation in a Cox Proportional Hazards Cure Model
- Flexible Cure Rate Modeling Under Latent Activation Schemes
- Flexible smoothing with \(B\)-splines and penalties. With comments and a rejoinder by the authors
- Ill-posed problems with counts, the composite link model and penalized likelihood
- Nonparametric additive location-scale models for interval censored data
- Optimal scaling for various Metropolis-Hastings algorithms.
- Random effects in promotion time cure rate models
- Robust specification of the roughness penalty prior distribution in spatially adaptive Bayesian P-splines models
- Semi-Parametric Estimation in Failure Time Mixture Models
- Semiparametric Transformation Models for Survival Data With a Cure Fraction
- Two-component mixture cure rate model with spline estimated nonparametric components
Cited in
(17)- Bayesian spectral density estimation using P-splines with quantile-based knot placement
- Spline-based estimation of cure rates: An application to the analysis of breast cancer data
- Special issue on advances in survival analysis
- Estimation and identification issues in the promotion time cure model when the same covariates influence long- and short-term survival
- Comments on: ``Nonparametric estimation in mixture cure models with covariates
- Automatic search intervals for the smoothing parameter in penalized splines
- Nonparametric double additive cure survival models: An application to the estimation of the non-linear effect of age at first parenthood on fertility progression
- Flexible objective Bayesian linear regression with applications in survival analysis
- Computationally Efficient Estimation for the Generalized Odds Rate Mixture Cure Model With Interval-Censored Data
- Fast Bayesian inference using Laplace approximations in a flexible promotion time cure model based on P-splines
- Laplacian-P-splines for Bayesian inference in the mixture cure model
- Censored quantile regression survival models with a cure proportion
- A flexible model for survival data with a cure rate: a Bayesian approach
- Hazard rate estimation for left truncated and right censored data
- The expectation-maximization approach for Bayesian additive Cox regression with current status data
- scientific article; zbMATH DE number 6775481 (Why is no real title available?)
- The Log-Normal zero-inflated cure regression model for labor time in an African obstetric population
This page was built for publication: Flexible estimation in cure survival models using Bayesian P-splines
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1660213)
