G-protein activation

Community: MathModDB

continuous-time expression

mathematical expression

Available identifiers

MaRDI QIDQ6773493

reaction describing the constitutive G-protein activation

Description

The constitutive G-protein activation, where we simply use R2 without ligand. That is, we model the constitutive binding reaction as a net reaction consisting of first the switching of GTP and GDP, followed by the dissociation of the βγ-subunit from the GPCR complex.

Defining Formula: $f_{11}=k_{11}\cdot x_R\cdot x_{\alpha \text{GDP}\beta \gamma }$

$k_{11}$ represents reaction constant for G-protein activation

$x_R$ represents number of receptor molecules

$x_{{\alpha }_{GDP}\beta \gamma }$ represents number of G-protein molecules

$f_{11}$ represents propensity of G-protein activation

Further items linking to G-protein activation

Item	Property
stochastic signalling of G‑protein coupled receptors model	contains

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