Functional additive models for optimizing individualized treatment rules
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Abstract: A novel functional additive model is proposed which is uniquely modified and constrained to model nonlinear interactions between a treatment indicator and a potentially large number of functional and/or scalar pretreatment covariates. The primary motivation for this approach is to optimize individualized treatment rules based on data from a randomized clinical trial. We generalize functional additive regression models by incorporating treatment-specific components into additive effect components. A structural constraint is imposed on the treatment-specific components in order to provide a class of additive models with main effects and interaction effects that are orthogonal to each other. If primary interest is in the interaction between treatment and the covariates, as is generally the case when optimizing individualized treatment rules, we can thereby circumvent the need to estimate the main effects of the covariates, obviating the need to specify their form and thus avoiding the issue of model misspecification. The methods are illustrated with data from a depression clinical trial with electroencephalogram functional data as patients' pretreatment covariates.
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Cites work
- A generalization error for Q-learning
- A simple method for estimating interactions between a treatment and a large number of covariates
- Combining biomarkers to optimize patient treatment recommendations
- Efficient augmentation and relaxation learning for individualized treatment rules using observational data
- Estimating individualized treatment rules using outcome weighted learning
- Estimation of treatment policies based on functional predictors
- Functional additive regression
- Functional data analysis
- Functional feature construction for individualized treatment regimes
- Functional response additive model estimation with online virtual stock markets
- High-dimensional inference for personalized treatment decision
- scientific article; zbMATH DE number 47282 (Why is no real title available?)
- scientific article; zbMATH DE number 2015204 (Why is no real title available?)
- scientific article; zbMATH DE number 845714 (Why is no real title available?)
- New statistical learning methods for estimating optimal dynamic treatment regimes
- Performance guarantees for individualized treatment rules
- Robust learning for optimal treatment decision with NP-dimensionality
- Sparse additive models
- Treatment decisions based on scalar and functional baseline covariates
- Tree-based methods for individualized treatment regimes
Cited in
(6)- A single-index model with multiple-links
- Nonlinear predictive directions in clinical trials
- Treatment decisions based on scalar and functional baseline covariates
- Estimation of treatment policies based on functional predictors
- A constrained single‐index regression for estimating interactions between a treatment and covariates
- Semiparametric partial functional regression model for estimating optimal individualized treatment regime
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