Functional uniform priors for nonlinear modeling

DOI10.1111/J.1541-0420.2012.01747.XMaRDI QIDQ4649070zbMATH OpenOpenAlexWikidataFDO

Authors Björn Bornkamp

Publication date 19 November 2012

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1110.4400

zbMATH Keywords

dose-findingnonlinear regressionpacking numbersdose-responseBayesian optimal designs

Mathematics Subject Classification ID

Bayesian inference (62F15) General nonlinear regression (62J02) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: This paper considers the topic of finding prior distributions when a major component of the statistical model depends on a nonlinear function. Using results on how to construct uniform distributions in general metric spaces, we propose a prior distribution that is uniform in the space of functional shapes of the underlying nonlinear function and then back-transform to obtain a prior distribution for the original model parameters. The primary application considered in this article is nonlinear regression, but the idea might be of interest beyond this case. For nonlinear regression the so constructed priors have the advantage that they are parametrization invariant and do not violate the likelihood principle, as opposed to uniform distributions on the parameters or the Jeffrey's prior, respectively. The utility of the proposed priors is demonstrated in the context of nonlinear regression modelling in clinical dose-finding trials, through a real data example and simulation. In addition the proposed priors are used for calculation of an optimal Bayesian design.

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Cited in

(6)

• Optimal designs for nonlinear regression models with respect to non-informative priors
• Practical considerations for using functional uniform prior distributions for dose-response estimation in clinical trials
• scientific article; zbMATH DE number 5586079 (Why is no real title available?)
• A machine learning compatible method for ordinal propensity score stratification and matching
• Functional Horseshoe Priors for Subspace Shrinkage
• Analysis of clinical trials with biologics using dose-time-response models

Describes a project that uses

Uses Software

• Runuran
• DoseFinding
• R

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