GRIN2

Authors Abdelrahman Elsayed, Xueyuan Cao, Stan Pounds, Lakshmi Anuhya Patibandla

Last update 22 August 2026

Copyright license GNU General Public License

Software version identifier 1.0, 2.0.0, PACKAGES.rds, 2.1.0

Description

Implements the Genomic Random Interval (GRIN) framework for identifying genomic loci affected by genomic lesions more frequently than expected by chance. Supports multiple lesion classes, lesion constellation analysis, exon-level target-size modeling, genomic lesion visualization, and gene-level association analyses linking genomic lesions or gene expression with binary and time-to-event clinical outcomes. Includes tools for retrieving versioned GRCh38 Ensembl gene, exon, and regulatory-element annotations. The statistical framework is described in Pounds et al. (2013) <doi:10.1093/bioinformatics/btt372>.

Cites work

A genomic random interval model for statistical analysis of genomic lesion data

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