gcmrec
Parameter estimation for the general class of semiparametric models for recurrent event data proposed by Peña and Hollander (2004, <ISBN:978-1-4020-7737-6>). The model incorporates an effective age function encoding the impact of interventions after each event occurrence, the effect of accumulating event occurrences, a link function for possibly time-dependent covariates, and optional gamma frailties to induce dependence among inter-event times. It also fits the extension for cancer relapses of González et al. (2005) <doi:10.1002/sim.2410>. Estimation is performed by profile likelihood, with an expectation-maximization algorithm for the frailty model, and the package provides descriptive, diagnostic and predictive tools for the fitted models.
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